DRAVP ID  DRAVPe01822

Peptide Name   BF-30

Sequence  KFFRKKSVKK

Sequence Length  10

UniProt ID  No entry found

Taxon ID  None

Source  Bungarus fasciatus

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  Influenza A virus

Assay  Cytopathic effect (CPE) reduction assay

Activity 

• [Ref.30447229]Influenza A virus H1N1:inhibition of viral replication in MDCK cells(EC50=5.20±0.9 μM);
• influenza A virus H3N2: inhibition of viral replication in MDCK cells(EC50=7.36 ± 1.2 μM);
• influenza A virus(oseltamivir-resistant strain): inhibition of viral replication in MDCK cells(EC50=18.91 ± 7.0 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30447229]MDCK cells:CC50=67.7μM.

Binding Target  Not found

Mechanism  BF-30 could inhibit the replication of various influenza subtypes by fusing virion membranes and reducing infectivity.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of peptide BF-30 on influenza A virus infection in vitro/vivo by causing virion membrane fusion.

Pubmed ID   30447229

Reference   Peptides. 2019 Feb;112:14-22.

Author   Xu J, Chen S, Jin J, Ma L, Guo M, Zhou C, Dou J.

DOI   10.1016/j.peptides.2018.10.004