General Information

General Information

DRAVP ID DRAVPe01822

Peptide Name BF-30

Sequence KFFRKKSVKK

Sequence Length 10

UniProt ID No entry found

Source Bungarus fasciatus

Activity Information

Target Organism Influenza A virus

Assay Cytopathic effect (CPE) reduction assay

Activity

[Ref.30447229]Influenza A virus H1N1:inhibition of viral replication in MDCK cells(EC50=5.20±0.9 μM);
influenza A virus H3N2: inhibition of viral replication in MDCK cells(EC50=7.36 ± 1.2 μM);
influenza A virus(oseltamivir-resistant strain): inhibition of viral replication in MDCK cells(EC50=18.91 ± 7.0 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30447229]MDCK cells:CC50=67.7μM.

Binding Target Not found

Mechanism BF-30 could inhibit the replication of various influenza subtypes by fusing virion membranes and reducing infectivity.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C62H106N18O12

Absent amino acids ACDEGHILMNPQTWY

Common amino acids K

Mass 1295.64

Pl 11.39

Basic residues 6

Acidic residues 0

Hydrophobic residues 3

Net charge 6

Boman Index -3607

Hydrophobicity -150

Aliphatic Index 29

Half Life

Mammalian:1.3 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Inhibition of peptide BF-30 on influenza A virus infection in vitro/vivo by causing virion membrane fusion.

Pubmed ID 30447229

Reference Peptides. 2019 Feb;112:14-22.

Author Xu J, Chen S, Jin J, Ma L, Guo M, Zhou C, Dou J.

DOI 10.1016/j.peptides.2018.10.004