General Information


DRAVP ID  DRAVPe01824

Peptide Name   SP40

Sequence  QMRRKVELFTYMRFD

Sequence Length  15

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  EV-A71

Assay  cell protection assay

Activity 

  • [Ref.34314773]Enterovirus A71 (EV-A71):inhibition of viral replication into RD cells(IC50=18 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.34314773]RD cells: CC50=228.7 μM.

Binding Target  Not found

Mechanism  SP40 peptide could associate with the cellular receptors at the surface of cells and prevented the attachment of EV-A71 to the cellular receptors



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Free

Stereochemistry  L



Physicochemical Information


Formula  C90H142N26O23S2

Absent amino acids  ACGHINPSW

Common amino acids  R

Mass  2020.4

Pl  9.98

Basic residues  4

Acidic residues  2

Hydrophobic residues  4

Net charge  2

Boman Index  -5447

Hydrophobicity  -83.33

Aliphatic Index  45.33

Half Life 

  •     Mammalian:0.8 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  106.43

Polar residues  2



Literature Information


Literature 1

Title   Stability and antiviral activity of SP40 peptide in human serum.

Pubmed ID   34314773

Reference   Virus Res. 2021 Oct 2;303:198456.

Author   Zarif F, Anasir MI, Koh JX, Chew MF, Poh CL.

DOI   10.1016/j.virusres.2021.198456.