General Information


DRAVP ID  DRAVPe01824

Peptide Name   SP40

Sequence  QMRRKVELFTYMRFD

Sequence Length  15

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  EV-A71

Assay  cell protection assay

Activity 

  • [Ref.34314773]Enterovirus A71 (EV-A71):inhibition of viral replication into RD cells(IC50=18 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.34314773]RD cells: CC50=228.7 μM.

Binding Target  Not found

Mechanism  SP40 peptide could associate with the cellular receptors at the surface of cells and prevented the attachment of EV-A71 to the cellular receptors



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Free

Stereochemistry  L



Physicochemical Information


Formula  C90H142N26O23S2

Absent amino acids  ACGHINPSW

Common amino acids  R

Mass  2020.4

Pl  9.98

Basic residues  4

Acidic residues  2

Hydrophobic residues  4

Net charge  2

Boman Index  -5447

Hydrophobicity  -83.33

Aliphatic Index  45.33

Half Life 

  •     Mammalian:0.8 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  106.43

Polar residues  2



Literature Information


Literature 1

Title   Stability and antiviral activity of SP40 peptide in human serum.

Pubmed ID   34314773

Reference   Virus Res. 2021 Oct 2;303:198456.

Author   Zarif F, Anasir MI, Koh JX, Chew MF, Poh CL.

DOI   10.1016/j.virusres.2021.198456.