General Information


DRAVP ID  DRAVPe01827

Peptide Name   TP3

Sequence  RKVELFTYMRFD

Sequence Length  12

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  EV-A71

Assay  cell protection assay

Activity 

  • [Ref.34314773]Enterovirus A71 (EV-A71):inhibition of viral replication into RD cells(IC50=5.7 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.34314773]RD cells: CC50=1123 μM.

Binding Target  Not found

Mechanism  The peptide could associate with the cellular receptors at the surface of cells and prevented the attachment of EV-A71 to the cellular receptors.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Free

Stereochemistry  L



Physicochemical Information


Formula  C74H113N19O19S

Absent amino acids  ACGHINPQSW

Common amino acids  FR

Mass  1604.89

Pl  8.59

Basic residues  3

Acidic residues  2

Hydrophobic residues  4

Net charge  1

Boman Index  -3636

Hydrophobicity  -53.33

Aliphatic Index  56.67

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  1490

Absorbance 280nm  135.45

Polar residues  2



Literature Information


Literature 1

Title   Stability and antiviral activity of SP43 peptide in human serum.

Pubmed ID   34314773

Reference   Virus Res. 2021 Oct 2;303:198456.

Author   Zarif F, Anasir MI, Koh JX, Chew MF, Poh CL.

DOI   10.1016/j.virusres.2021.198456.