General Information


DRAVP ID  DRAVPe01829

Peptide Name   KP

Sequence  AKVTMTCSAS

Sequence Length  10

UniProt ID  P01680 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV-1

Assay  Plaque reduction assay

Activity 

  • [Ref.30654366]HSV-1:inhibition of viral replication in Vero cells (96% inhibition at 50 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C39H71N11O15S2

Absent amino acids  DEFGHILNPQRWY

Common amino acids  AST

Mass  998.18

Pl  8.27

Basic residues  1

Acidic residues  0

Hydrophobic residues  3

Net charge  1

Boman Index  -620

Hydrophobicity  53

Aliphatic Index  49

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID   30654366

Reference   Intervirology. 2018;61(4):166-173.

Author   Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI   10.1159/000494354