General Information


DRAVP ID  DRAVPe01829

Peptide Name   KP

Sequence  AKVTMTCSAS

Sequence Length  10

UniProt ID  P01680 

Source  Synthetic construct



Activity Information


Target Organism  HSV-1

Assay  Plaque reduction assay

Activity 

  • [Ref.30654366]HSV-1:inhibition of viral replication in Vero cells (96% inhibition at 50 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C39H71N11O15S2

Absent amino acids  DEFGHILNPQRWY

Common amino acids  AST

Mass  998.18

Pl  8.27

Basic residues  1

Acidic residues  0

Hydrophobic residues  3

Net charge  1

Boman Index  -620

Hydrophobicity  53

Aliphatic Index  49

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID   30654366

Reference   Intervirology. 2018;61(4):166-173.

Author   Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI   10.1159/000494354