DRAVP ID  DRAVPe01830

Peptide Name   K10S

Sequence  KKVTMTCSAS

Sequence Length  10

UniProt ID  P01680 

Source  Synthetic construct

Target Organism  HSV-1, CoxV B5, AdV, VSV

Assay  Plaque reduction assay

Activity 

• [Ref.30654366]HSV-1:inhibition of viral replication in Vero cells (45% inhibition at 10 µg/ml, 76% inhibition at 50 µg/ml, 89% inhibition at 100 µg/ml);
• Coxsackie virus B5:inhibition of viral replication in Vero cells (75% inhibition at 50 µg/ml, 94% inhibition at 100 µg/ml);
• Vesicular Stomatitis Virus (VSV):inhibition of viral replication in Vero cells (78% inhibition at 50 µg/ml, 96% inhibition at 100 µg/ml);
• Adenovirus:inhibition of viral replication in Vero cells (75% inhibition at 50 µg/ml, 91% inhibition at 100 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30654366]20% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID   30654366

Reference   Intervirology. 2018;61(4):166-173.

Author   Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI   10.1159/000494354