General Information

General Information

DRAVP ID DRAVPe01831

Peptide Name L5A

Sequence NQVSATCSVK

Sequence Length 10

UniProt ID P0DOX5

Source Synthetic construct

Activity Information

Target Organism VSV

Assay Plaque reduction assay

Activity

[Ref.30654366]Vesicular Stomatitis Virus (VSV):inhibition of viral replication in Vero cells (45% inhibition at 50 µg/ml, 50% inhibition at 100 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30654366]20% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C41H73N13O16S

Absent amino acids DEFGHILMPRWY

Common amino acids SV

Mass 1036.17

Pl 8.22

Basic residues 1

Acidic residues 0

Hydrophobic residues 3

Net charge 1

Boman Index -1593

Hydrophobicity -5

Aliphatic Index 68

Half Life

Mammalian:1.4 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID 30654366

Reference Intervirology. 2018;61(4):166-173.

Author Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI 10.1159/000494354