General Information

General Information

DRAVP ID DRAVPe01832

Peptide Name K13L

Sequence KKLVAASQAALGL

Sequence Length 13

UniProt ID P02768-2

Source Synthetic construct

Activity Information

Target Organism CoxV B5

Assay Plaque reduction assay

Activity

[Ref.30654366]Coxsackie virus B5:inhibition of viral replication in Vero cells (60% inhibition at 10 µg/ml, 80% inhibition at 50 µg/ml, 87% inhibition at 100 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30654366]30% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C57H104N16O16

Absent amino acids CDEFHIMNPRTWY

Common amino acids A

Mass 1269.55

Pl 10

Basic residues 2

Acidic residues 0

Hydrophobic residues 8

Net charge 2

Boman Index 694

Hydrophobicity 79.23

Aliphatic Index 143.08

Half Life

Mammalian:1.3 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID 30654366

Reference Intervirology. 2018;61(4):166-173.

Author Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI 10.1159/000494354