General Information

General Information

DRAVP ID DRAVPe01833

Peptide Name D15R

Sequence DSGEGDFLAEGGGVR

Sequence Length 15

UniProt ID P02671

Source Synthetic construct

Activity Information

Target Organism CoxV B5

Assay Plaque reduction assay

Activity

[Ref.30654366]Coxsackie virus B5:inhibition of viral replication in Vero cells (82% inhibition at 10 µg/ml, 85% inhibition at 50 µg/ml, 93% inhibition at 100 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C60H92N18O25

Absent amino acids CHIKMNPQTWY

Common amino acids G

Mass 1465.5

Pl 3.92

Basic residues 1

Acidic residues 4

Hydrophobic residues 4

Net charge -3

Boman Index -3093

Hydrophobicity -58

Aliphatic Index 52

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Literature Information

Literature 1

Title Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID 30654366

Reference Intervirology. 2018;61(4):166-173.

Author Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI 10.1159/000494354