General Information

General Information

DRAVP ID DRAVPe01834

Peptide Name G17K

Sequence GLEEELQFSLGSKINVK

Sequence Length 17

UniProt ID P0C0L5

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism CoxV B5

Assay Plaque reduction assay

Activity

[Ref.30654366]Coxsackie virus B5:inhibition of viral replication in Vero cells (60% inhibition at 10 µg/ml, 75% inhibition at 50 µg/ml, 88% inhibition at 100 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C84H139N21O28

Absent amino acids ACDHMPRTWY

Common amino acids EL

Mass 1891.15

Pl 4.79

Basic residues 2

Acidic residues 3

Hydrophobic residues 6

Net charge -1

Boman Index -2193

Hydrophobicity -28.24

Aliphatic Index 108.82

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID 30654366

Reference Intervirology. 2018;61(4):166-173.

Author Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI 10.1159/000494354