General Information

General Information

DRAVP ID DRAVPe01835

Peptide Name S17K

Sequence SEETKENEGFTVTAEGK

Sequence Length 17

UniProt ID P01024

Source Synthetic construct

Activity Information

Target Organism AdV

Assay Plaque reduction assay

Activity

[Ref.30654366]Adenovirus:inhibition of viral replication in Vero cells (60% inhibition at 10 µg/ml, 65% inhibition at 50 µg/ml, 80% inhibition at 100 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C77H122N20O33

Absent amino acids CDHILMPQRWY

Common amino acids E

Mass 1855.93

Pl 4.32

Basic residues 2

Acidic residues 5

Hydrophobic residues 3

Net charge -3

Boman Index -5219

Hydrophobicity -139.41

Aliphatic Index 22.94

Half Life

Mammalian:1.9 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 7

Literature Information

Literature 1

Title Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID 30654366

Reference Intervirology. 2018;61(4):166-173.

Author Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI 10.1159/000494354