DRAVP ID  DRAVPe01836

Peptide Name   L12P

Sequence  LCLRNWDQGHRP

Sequence Length  12

UniProt ID  A0M8Q8 

Source  Synthetic construct

Target Organism  HSV-1, CoxV B5

Assay  Plaque reduction assay

Activity 

• [Ref.30654366]HSV-1:inhibition of viral replication in Vero cells (78% inhibition at 10 µg/ml, 84% inhibition at 50 µg/ml);
• Coxsackie virus B5:inhibition of viral replication in Vero cells (60% inhibition at 10 µg/ml, 42% inhibition at 50 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID   30654366

Reference   Intervirology. 2018;61(4):166-173.

Author   Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI   10.1159/000494354