DRAVP ID  DRAVPe01836

Peptide Name   L12P

Sequence  LCLRNWDQGHRP

Sequence Length  12

UniProt ID  A0M8Q8 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV-1, CoxV B5

Assay  Plaque reduction assay

Activity 

• [Ref.30654366]HSV-1:inhibition of viral replication in Vero cells (78% inhibition at 10 µg/ml, 84% inhibition at 50 µg/ml);
• Coxsackie virus B5:inhibition of viral replication in Vero cells (60% inhibition at 10 µg/ml, 42% inhibition at 50 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100μg/ mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins.

Pubmed ID   30654366

Reference   Intervirology. 2018;61(4):166-173.

Author   Sala A, Ardizzoni A, Ciociola T, Magliani W, Conti S, Blasi E, Cermelli C

DOI   10.1159/000494354