To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01844
Peptide Name Entry 12
Sequence GKRKSXAX
Sequence Length 8
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism DENV
Assay Fluorimetric assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target NS2B-NS3 protease
Mechanism The cyclic peptide could inhibit the activity of NS2B-NS3 protease, which is an essential enzyme for the replication of dengue virus.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification No specific N-terminal
C-terminal Modification No specific C-terminal
Other Modification The 'X' at position 6 indicates homophenylalanine(hPhe), position 8 indicates homophenylalanine(Phg). The N-terminal and C-terminal cyclized by a amide bond.
Stereochemistry L
Physicochemical Information
Formula C26H47N11O6
Absent amino acids CDEFHILMNPQTVWY
Common amino acids KX
Mass 868.42
Pl 11.17
Basic residues 3
Acidic residues 0
Hydrophobic residues 1
Net charge 3
Boman Index -2667
Hydrophobicity -146.25
Aliphatic Index 12.5
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Discovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity.
Pubmed ID 28539222
Reference Bioorg Med Chem Lett. 2017 Aug 1;27(15):3586-3590.
Author Takagi Y, Matsui K, Nobori H, Maeda H, Sato A, Kurosu T, Orba Y, Sawa H, Hattori K, Higashino K, Numata Y, Yoshida Y.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.