General Information

General Information

DRAVP ID DRAVPe01867

Peptide Name DET4

Sequence AGVKDGKLDF

Sequence Length 10

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism DENV

Assay Plaque formation assay

Activity

[Ref.23630436]dengue virus 2(DENV2):inhibition of viral replication in LLC-MK2 cells(84.6±5.6% inhibition at 500 µM, IC50=35 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.23630436]Monkey kidney epithelial cells LLC-MK2: 5% Cell death at 500 µM.

Binding Target E protein

Mechanism The peptide caused structural abnormalities and alteration of the arrangement of the viral E protein, which interferes with virus binding and entry.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C47H76N12O15

Absent amino acids CEHIMNPQRSTWY

Common amino acids DGK

Mass 1049.19

Pl 6

Basic residues 2

Acidic residues 2

Hydrophobic residues 4

Net charge 0

Boman Index -1291

Hydrophobicity -30

Aliphatic Index 78

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Inhibition of dengue virus entry into target cells using synthetic antiviral peptides.

Pubmed ID 23630436

Reference Int J Med Sci. 2013 Apr 16;10(6):719-29.

Author Alhoot MA, Rathinam AK, Wang SM, Manikam R, Sekaran SD.

DOI 10.7150/ijms.5037