DRAVP ID  DRAVPe01871

Peptide Name   FP4

Sequence  RRKKWLVFFVIFYFFR

Sequence Length  16

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  Influenza virus

Assay  Plaque reduction assay

Activity 

• [Ref.22258859]influenza A virus A/WSN/33 H1N1:inhibition of viral replication in MDCK cells(IC50=0.00004 µM);
• influenza A virus PR8/Eng09 (H1N1):inhibition of viral replication in MDCK cells(IC50=0.0778 µM);
• influenza A virus PR8/Vic (H3N2):inhibition of viral replication in MDCK cells(IC50=0.0535 µM);
• influenza A virus PR8/Viet (H5N1):inhibition of viral replication in MDCK cells(IC50=0.1325 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  HA

Mechanism  the mechanism whereby FluPep mediates its antiviral effects is likely to involve inhibiting the binding of HA to sialic acid receptors or through interference with the fusion process by blocking protease cleavage.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A novel family of peptides with potent activity against influenza A viruses.

Pubmed ID   22258859

Reference   J Gen Virol. 2012 May;93(Pt 5):980-986.

Author   Nicol MQ, Ligertwood Y, Bacon MN, Dutia BM, Nash AA.

DOI   10.1099/vir.0.038679-0