General Information


DRAVP ID  DRAVPe01877

Peptide Name   HPV-16 L2 Ct

Sequence  MLRKRRKRL

Sequence Length  9

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HPV

Assay  luminescence assay

Activity 

  • [Ref.15170645]human papillomavirus(HPV):inhibition of HPV virus-like particle cell entry(78±6% inhibition at 10 μg/ml); inhibition of pseudovirions infection(96±20% inhibition at 10 μg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C53H105N23O10S

Absent amino acids  ACDEFGHINPQSTVWY

Common amino acids  R

Mass  1256.62

Pl  12.48

Basic residues  6

Acidic residues  0

Hydrophobic residues  2

Net charge  6

Boman Index  -5859

Hydrophobicity  -181.11

Aliphatic Index  86.67

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Positively charged synthetic peptides from structural proteins of papillomaviruses abrogate human papillomavirus infectivity.

Pubmed ID   15170645

Reference   J Med Virol. 2004 Jul;73(3):474-80.

Author   Bousarghin L, Touzé A, Yvonnet B, Coursaget P.

DOI   10.1002/jmv.20114