General Information

General Information

DRAVP ID DRAVPe01880

Peptide Name Loop3

Sequence ATSSANSKA

Sequence Length 9

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism JEV

Assay Plaque assay

Activity

[Ref.22465300]Japanese encephalitis virus(JEV):inhibition of viral replication in BHK-21 cells(IC50=10 ± 1.4 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.22465300]Did not stimulate significant cytotoxicity in BHK-21 cells even at 200 μM.

Binding Target Envelope protein

Mechanism prevent JEV infection by interfering in virus attachment to the cells.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C32H57N11O15

Absent amino acids CDEFGHILMPQRVWY

Common amino acids AS

Mass 835.87

Pl 8.8

Basic residues 1

Acidic residues 0

Hydrophobic residues 3

Net charge 1

Boman Index -1953

Hydrophobicity -56.67

Aliphatic Index 33.33

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Inhibition of Japanese encephalitis virus entry into the cells by the envelope glycoprotein domain III (EDIII) and the loop3 peptide derived from EDIII.

Pubmed ID 22465300

Reference Antiviral Res. 2012 May;94(2):179-83.

Author Li C, Zhang LY, Sun MX, Li PP, Huang L, Wei JC, Yao YL, Isahg H, Chen PY, Mao X.

DOI 10.1016/j.antiviral.2012.03.002