DRAVP ID  DRAVPe01881

Peptide Name   C24

Sequence  SISNALNKLEESNRNLDKVNVKLT

Sequence Length  24

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  NDV

Assay  Plaque reduction assay

Activity 

• [Ref.12127571]Newcastle disease virus (NDV):inhibition of syncytium formation between NDV-infected cells(IC50=3.27 μM)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  F protein

Mechanism  By binding to the opposite HR region in the F protein, peptides would inhibit fusion from the initial steps (lipid- and contents-mixing), blocking the conformational changes in the fusion protein required for triggering fusion.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Mode of action of two inhibitory peptides from heptad repeat domains of the fusion protein of Newcastle disease virus.

Pubmed ID   12127571

Reference   Int J Biochem Cell Biol. 2002 Oct;34(10):1207-20.

Author   San Román K, Villar E, Muñoz-Barroso I.

DOI   10.1016/s1357-2725(02)00045-6