To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01882
Peptide Name N24
Sequence KQNAANILRLKESIAATNEAVHEV
Sequence Length 24
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism NDV
Assay Plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target F protein
Mechanism By binding to the opposite HR region in the F protein, peptides would inhibit fusion from the initial steps (lipid- and contents-mixing), blocking the conformational changes in the fusion protein required for triggering fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C112H191N35O37
Absent amino acids CDFGMPWY
Common amino acids A
Mass 2619.96
Pl 6.76
Basic residues 4
Acidic residues 3
Hydrophobic residues 11
Net charge 1
Boman Index -4573
Hydrophobicity -31.25
Aliphatic Index 110
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Literature Information
Literature 1
Title Mode of action of two inhibitory peptides from heptad repeat domains of the fusion protein of Newcastle disease virus.
Pubmed ID 12127571
Reference Int J Biochem Cell Biol. 2002 Oct;34(10):1207-20.
Author San Román K, Villar E, Muñoz-Barroso I.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.