General Information


DRAVP ID  DRAVPe01883

Peptide Name   HLFcin 1-49

Sequence  GRRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQA

Sequence Length  49

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HPV

Assay  Western blotting

Activity 

  • [Ref.17481742]human papillomavirus(HPV):inhibition of pseudovirus infection in C33A cells(IC50=0.32±0.18μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Disulfide bonds between Cys10 and Cys46, Cys20 and Cys37.

Stereochemistry  L



Physicochemical Information


Formula  C244H403N85O66S5

Absent amino acids  HLY

Common amino acids  R

Mass  5743.71

Pl  11.24

Basic residues  11

Acidic residues  2

Hydrophobic residues  13

Net charge  9

Boman Index  -15425

Hydrophobicity  -85.1

Aliphatic Index  53.67

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  11250

Absorbance 280nm  234.38

Polar residues  12



Literature Information


Literature 1

Title   The anti-papillomavirus activity of human and bovine lactoferricin.

Pubmed ID   17481742

Reference   Antiviral Res. 2007 Sep;75(3):258-65.

Author   Mistry N, Drobni P, Näslund J, Sunkari VG, Jenssen H, Evander M.

DOI   10.1016/j.antiviral.2007.03.012