General Information


DRAVP ID  DRAVPe01884

Peptide Name   BLfcinB 17-42

Sequence  FKCRRWQWRMKKLGAPSITCVRRAFA

Sequence Length  26

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HPV

Assay  Western blotting

Activity 

  • [Ref.17481742]human papillomavirus(HPV):inhibition of pseudovirus infection in C33A cells(IC50=0.25±0.24 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Disulfide bonds between Cys3 and Cys20.

Stereochemistry  L



Physicochemical Information


Formula  C144H231N47O30S3

Absent amino acids  DEHNY

Common amino acids  R

Mass  3196.9

Pl  11.84

Basic residues  8

Acidic residues  0

Hydrophobic residues  10

Net charge  8

Boman Index  -6698

Hydrophobicity  -48.46

Aliphatic Index  52.69

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  11125

Absorbance 280nm  445

Polar residues  5



Literature Information


Literature 1

Title   The anti-papillomavirus activity of human and bovine lactoferricin.

Pubmed ID   17481742

Reference   Antiviral Res. 2007 Sep;75(3):258-65.

Author   Mistry N, Drobni P, Näslund J, Sunkari VG, Jenssen H, Evander M.

DOI   10.1016/j.antiviral.2007.03.012