General Information

General Information

DRAVP ID DRAVPe01885

Peptide Name None

Sequence AGDDQGLDKCVPNSKEK

Sequence Length 17

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism Influenza A virus

Assay Hemagglutinin assay

Activity

[Ref.22595270]Influenza A virus (A/Roma-ISS/2/08 H1N1):inhibition of viral replication in MDCK cells(EC50=3.7±0.35 pM);
Influenza A virus (A/Parma/24/09 H1N1):inhibition of viral replication in MDCK cells(EC50=3.4±0.14 pM);
Influenza A virus (A/Parma/05/06 H3N2):inhibition of viral replication in MDCK cells(EC50=7.3±0.65 pM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.22595270]MDCK cells:CC50>25 μM.

Binding Target HA

Mechanism The peptide may bind with HA and precent the attachment to target cells.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C73H122N22O29S

Absent amino acids FHIMRTWY

Common amino acids DK

Mass 1803.96

Pl 4.68

Basic residues 3

Acidic residues 4

Hydrophobic residues 3

Net charge -1

Boman Index -5127

Hydrophobicity -138.82

Aliphatic Index 45.88

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus.

Pubmed ID 22595270

Reference Pathog Glob Health. 2012 Mar;106(1):12-9.

Author Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F.

DOI 10.1179/2047773212Y.0000000004