DRAVP ID  DRAVPe01887

Peptide Name   None

Sequence  SKHSSLDCVLRP

Sequence Length  12

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  Influenza A virus

Assay  Hemagglutinin assay

Activity 

• [Ref.22595270]Influenza A virus (A/Roma-ISS/2/08 H1N1):inhibition of viral replication in MDCK cells(EC50=4±0.37 pM);
• Influenza A virus (A/Parma/24/09 H1N1):inhibition of viral replication in MDCK cells(EC50=3.1±0.12 pM);
• Influenza A virus (A/Parma/05/06 H3N2):inhibition of viral replication in MDCK cells(EC50=5.8±0.7 pM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.22595270]MDCK cells:CC50>25 μM.

Binding Target  HA

Mechanism  The peptide may bind with HA and precent the attachment to target cells.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus.

Pubmed ID   22595270

Reference   Pathog Glob Health. 2012 Mar;106(1):12-9.

Author   Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F.

DOI   10.1179/2047773212Y.0000000004