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General Information
DRAVP ID DRAVPe01890
Peptide Name Subtilosin-A
Sequence NKGCATCSIGAACLVDGPIPDFEIAGAtGLfGLWG
Sequence Length 35
UniProt ID O07623
Source Bacillus subtilis
Activity Information
Target Organism HSV-2
Assay Plaque formation assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism Subtilosin displays antiviral and virucidal actions against HSV-2. The target of subtilosin inhibitory effect would be late stages of the viral replicative cycle such as viral glycoprotein intracellular transport.
Structure Information
PDB ID 1PXQ
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification No specific N-terminal
C-terminal Modification No specific C-terminal
Other Modification The N-terminal and C-terminal cyclized by a amide bond. Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22.
Stereochemistry Mixed(D-Thr28,D-Phe31)
Physicochemical Information
Formula C139H214N36O41S3
Absent amino acids HMQRY
Common amino acids G
Mass 3425.94
Pl 4.03
Basic residues 1
Acidic residues 3
Hydrophobic residues 14
Net charge -2
Boman Index 1593
Hydrophobicity 63.14
Aliphatic Index 89.43
Half Life
Extinction Coefficient cystines 5625
Absorbance 280nm 165.44
Polar residues 13
Literature Information
Literature 1
Title Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin.
Pubmed ID 25087911
Reference J Appl Microbiol. 2014 Nov;117(5):1253-9.
Author Quintana VM, Torres NI, Wachsman MB, Sinko PJ, Castilla V, Chikindas M.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.