General Information

General Information

DRAVP ID DRAVPe01891

Peptide Name EB

Sequence RRKKAAVALLPAVLLALLAP

Sequence Length 20

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism Influenza A virus

Assay Hemagglutinin assay

Activity

[Ref.17005658]Influenza A virus(A/Hong Kong/483/97 ([HK/483] strain H5N1)): inhibition of viral replication by preventing attachment to cRBCs(IC50=8 μM); inhibition of influenza virus-induced cell death and replication in vitro(IC50=4.5 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.17005658]No cytotoxicity against MDCK cells up to 50μM

Binding Target HA

Mechanism The binding of EB to HA could lead to a conformation change in HA, decreasing the affinity for sialic acids on the cell surface.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C98H178N28O21

Absent amino acids CDEFGHIMNQSTWY

Common amino acids AL

Mass 2084.67

Pl 12.02

Basic residues 4

Acidic residues 0

Hydrophobic residues 14

Net charge 4

Boman Index 752

Hydrophobicity 110

Aliphatic Index 176

Half Life

Mammalian:1 hour
Yeast:2 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells.

Pubmed ID 17005658

Reference J Virol. 2006 Dec;80(24):11960-7.

Author Jones JC, Turpin EA, Bultmann H, Brandt CR, Schultz-Cherry S.

DOI 10.1128/JVI.01678-06