DRAVP ID  DRAVPe01891

Peptide Name   EB

Sequence  RRKKAAVALLPAVLLALLAP

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  Influenza A virus

Assay  Hemagglutinin assay

Activity 

• [Ref.17005658]Influenza A virus(A/Hong Kong/483/97 ([HK/483] strain H5N1)): inhibition of viral replication by preventing attachment to cRBCs(IC50=8 μM); inhibition of influenza virus-induced cell death and replication in vitro(IC50=4.5 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.17005658]No cytotoxicity against MDCK cells up to 50μM

Binding Target  HA

Mechanism  The binding of EB to HA could lead to a conformation change in HA, decreasing the affinity for sialic acids on the cell surface. 

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells.

Pubmed ID   17005658

Reference   J Virol. 2006 Dec;80(24):11960-7.

Author   Jones JC, Turpin EA, Bultmann H, Brandt CR, Schultz-Cherry S.

DOI   10.1128/JVI.01678-06