General Information

General Information

DRAVP ID DRAVPe01892

Peptide Name EF

Sequence EF

Sequence Length 2

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism DENV

Assay Foci-forming reduction assay

Activity

[Ref.24612829]dengue virus 2(DENV2):inhibition of viral entry in Vero cells(IC50=96.50 µM); inhibition of viral replication in Vero cells(83.47% inhibition at 200 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.24612829]No cytotoxicity against Vero cells up to 500 µM.

Binding Target E protein

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C14H18N2O5

Absent amino acids ACDGHIKLMNPQRSTVWY

Common amino acids EF

Mass 294.31

Pl 4

Basic residues 0

Acidic residues 1

Hydrophobic residues 1

Net charge -1

Boman Index -383

Hydrophobicity -35

Aliphatic Index 0

Half Life

Mammalian:1 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Peptide inhibitors against dengue virus infection.

Pubmed ID 24612829

Reference Chem Biol Drug Des. 2014 Aug;84(2):148-57.

Author Panya A, Bangphoomi K, Choowongkomon K, Yenchitsomanus PT.

DOI 10.1111/cbdd.12309