General Information

General Information

DRAVP ID DRAVPe01892

Peptide Name EF

Sequence EF

Sequence Length 2

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism DENV

Assay Foci-forming reduction assay

Activity

[Ref.24612829]dengue virus 2(DENV2):inhibition of viral entry in Vero cells(IC50=96.50 µM); inhibition of viral replication in Vero cells(83.47% inhibition at 200 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.24612829]No cytotoxicity against Vero cells up to 500 µM.

Binding Target E protein

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C14H18N2O5

Absent amino acids ACDGHIKLMNPQRSTVWY

Common amino acids EF

Mass 294.31

Pl 4

Basic residues 0

Acidic residues 1

Hydrophobic residues 1

Net charge -1

Boman Index -383

Hydrophobicity -35

Aliphatic Index 0

Half Life

Mammalian:1 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Peptide inhibitors against dengue virus infection.

Pubmed ID 24612829

Reference Chem Biol Drug Des. 2014 Aug;84(2):148-57.

Author Panya A, Bangphoomi K, Choowongkomon K, Yenchitsomanus PT.

DOI 10.1111/cbdd.12309