General Information


DRAVP ID  DRAVPe01893

Peptide Name   KEN

Sequence  KEN

Sequence Length  3

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  DENV

Assay  Foci-forming reduction assay

Activity 

  • [Ref.24612829]dengue virus 2(DENV2):inhibition of viral entry in Vero cells(IC50=331.9 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.24612829]No cytotoxicity against Vero cells up to 500 µM.

Binding Target  E protein

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C15H27N5O7

Absent amino acids  ACDFGHILMPQRSTVWY

Common amino acids  EKN

Mass  389.41

Pl  6

Basic residues  1

Acidic residues  1

Hydrophobic residues  0

Net charge  0

Boman Index  -1900

Hydrophobicity  -363.33

Aliphatic Index  0

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Peptide inhibitors against dengue virus infection.

Pubmed ID   24612829

Reference   Chem Biol Drug Des. 2014 Aug;84(2):148-57.

Author   Panya A, Bangphoomi K, Choowongkomon K, Yenchitsomanus PT.

DOI   10.1111/cbdd.12309