General Information

General Information

DRAVP ID DRAVPe01896

Peptide Name H2-3

Sequence HGLLYFAIFFVAAWHIRGR

Sequence Length 19

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HCV

Assay

Activity

[Ref.26251517]Hepatitis C Virus(HCV):inhibition of viral infection in Huh7.5.1 cells(EC50=0.54 ± 0.08 μM); inhibition of post-infection in Huh7.5.1 cells(EC50=1.09 ± 0.11 μM);H2-3 peptide inactivated HCV(EC50=82.11 nM).

Hemolytic Activity

[Ref.26251517]<10% hemolysis even at 400 μM against human erythrocytes.

Cytotoxicity

[Ref.26251517]Huh7.5.1 cells: CC50=115.99 ± 16.68 μM;
Bel7402 cells:CC50~200 μM;
HeLa cells:CC50~200 μM.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C113H160N30O21

Absent amino acids CDEKMNPQST

Common amino acids AF

Mass 2274.7

Pl 10.84

Basic residues 4

Acidic residues 0

Hydrophobic residues 12

Net charge 4

Boman Index 300

Hydrophobicity 85.26

Aliphatic Index 113.16

Half Life

Mammalian:3.5 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 388.33

Polar residues 3

Literature Information

Literature 1

Title A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro.

Pubmed ID 26251517

Reference J Biol Chem. 2015 Sep 18;290(38):23254-63.

Author Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z.

DOI 10.1074/jbc.M115.662452