General Information

General Information

DRAVP ID DRAVPe01897

Peptide Name H3

Sequence WPFCLLLMAL

Sequence Length 10

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HCV

Assay

Activity

[Ref.26251517]Hepatitis C Virus(HCV):inhibition of viral infection in Huh7.5.1 cells(EC50=0.52 ± 0.07 μM); inhibition of post-infection in Huh7.5.1 cells(EC50=1.54 ± 0.73 μM).

Hemolytic Activity

[Ref.26251517]<10% hemolysis even at 400 μM against human erythrocytes.

Cytotoxicity

[Ref.26251517]Huh7.5.1 cells: CC50=47.22 ± 5.29 μM;
Bel7402 cells:CC50~200 μM;
HeLa cells:CC50~200 μM.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C60H91N11O11S2

Absent amino acids DEGHIKNQRSTVY

Common amino acids L

Mass 1206.57

Pl 5.52

Basic residues 0

Acidic residues 0

Hydrophobic residues 7

Net charge 0

Boman Index 3043

Hydrophobicity 217

Aliphatic Index 166

Half Life

Mammalian:2.8 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 5500

Absorbance 280nm 611.11

Polar residues 1

Literature Information

Literature 1

Title A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro.

Pubmed ID 26251517

Reference J Biol Chem. 2015 Sep 18;290(38):23254-63.

Author Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z.

DOI 10.1074/jbc.M115.662452