General Information

General Information

DRAVP ID DRAVPe01897

Peptide Name H3

Sequence WPFCLLLMAL

Sequence Length 10

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HCV

Assay

Activity

[Ref.26251517]Hepatitis C Virus(HCV):inhibition of viral infection in Huh7.5.1 cells(EC50=0.52 ± 0.07 μM); inhibition of post-infection in Huh7.5.1 cells(EC50=1.54 ± 0.73 μM).

Hemolytic Activity

[Ref.26251517]<10% hemolysis even at 400 μM against human erythrocytes.

Cytotoxicity

[Ref.26251517]Huh7.5.1 cells: CC50=47.22 ± 5.29 μM;
Bel7402 cells:CC50~200 μM;
HeLa cells:CC50~200 μM.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C60H91N11O11S2

Absent amino acids DEGHIKNQRSTVY

Common amino acids L

Mass 1206.57

Pl 5.52

Basic residues 0

Acidic residues 0

Hydrophobic residues 7

Net charge 0

Boman Index 3043

Hydrophobicity 217

Aliphatic Index 166

Half Life

Mammalian:2.8 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 5500

Absorbance 280nm 611.11

Polar residues 1

Literature Information

Literature 1

Title A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro.

Pubmed ID 26251517

Reference J Biol Chem. 2015 Sep 18;290(38):23254-63.

Author Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z.

DOI 10.1074/jbc.M115.662452