General Information

General Information

DRAVP ID DRAVPe01900

Peptide Name SL175

Sequence GWAGWLLSPRGSRPS

Sequence Length 15

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HCV

Assay ELISA

Activity

[Ref.19264632]hepatitis C virus(J6/JFH1):inhibition of viral infection in Huh-7.5 cells(50% inhibition at 20 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C74H111N23O19

Absent amino acids CDEFHIKMNQTVY

Common amino acids GS

Mass 1626.84

Pl 12

Basic residues 2

Acidic residues 0

Hydrophobic residues 5

Net charge 2

Boman Index -2091

Hydrophobicity -54.67

Aliphatic Index 58.67

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 11000

Absorbance 280nm 785.71

Polar residues 6

Literature Information

Literature 1

Title Peptide inhibitors of hepatitis C virus core oligomerization and virus production.

Pubmed ID 19264632

Reference J Gen Virol. 2009 Jun;90(Pt 6):1319-1328.

Author Kota S, Coito C, Mousseau G, Lavergne JP, Strosberg AD.

DOI 10.1099/vir.0.008565-0