General Information

General Information

DRAVP ID DRAVPe01903

Peptide Name PB1 (6–25)

Sequence TLLFLKVPAQNAISTTFPYT

Sequence Length 21

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism Influenza A virus

Assay Hemagglutination assay

Activity

[Ref.25446335]Influenza A virus(A/California/07/2009 (H1N1)pdm09/):antiviral activity of the peptide in MDCK cells(ED50=129 ± 2 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism The peptide may affect the early stages of the viral life cycle, which includes the synthesis of polymerase subunits and their subsequent assembly into functionally active complex. The peptide could interfere with these processes thus inhibiting virus replication.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C106H163N23O28

Absent amino acids CDEGHMRW

Common amino acids T

Mass 2225.61

Pl 8.26

Basic residues 1

Acidic residues 0

Hydrophobic residues 9

Net charge 1

Boman Index 175

Hydrophobicity 49.05

Aliphatic Index 97.62

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 1490

Absorbance 280nm 74.5

Polar residues 7

Literature Information

Literature 1

Title Synthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments.

Pubmed ID 25446335

Reference Antiviral Res. 2015 Jan;113:4-10.

Author Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI.

DOI 10.1016/j.antiviral.2014.10.015