DRAVP ID  DRAVPe01934

Peptide Name   AVP-p

Sequence  LNLFKKTINGLISDSLVIR

Sequence Length  19

UniProt ID  A0A7D5DRX8  P03540 

Taxon ID  3052300 

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  GPC

GenBank  QLA46850.1

Amino Acid position  348 to 366

Domain Accession ID  pfam00798 

Nucleotide sequence ID  MK896487 

Molecular Type  Genomic RNA

Chromosomal Position  Not Available

Target Organism  PICV,JUNV

Assay  Plaque reduction assay

Activity 

• [Ref.24850726]Pichinde virus (PICV):inhibition of viral infection in Vero cells(IC50=7.05 ± 2.19 μM);
• Arenaviruses (TAMV, JUNV, MACV, LASV): Inhibition (IC50 = 2–10 μM);
• Complete inhibition of viral plaque formation at ~20 μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.24850726]No significant loss of viability was observed in Vero cells or human foreskin fibroblasts (HFF) up to 100 μM.

Binding Target  Membrane

Mechanism  That untimely deployment of fusion machinery by the peptide could render virions less able to engage in on-pathway receptor binding or endosomal fusion.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of arenavirus infection by a glycoprotein-derived peptide with a novel mechanism.

Pubmed ID   24850726

Reference   J Virol. 2014 Aug;88(15):8556-64.

Author   Spence JS, Melnik LI, Badani H, Wimley WC, Garry RF.

DOI   10.1128/JVI.01133-14