General Information


DRAVP ID  DRAVPe01936

Peptide Name   E50,51TAT-Cd0

Sequence  GREERRQRRRC

Sequence Length  11

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV-1

Assay  Antiviral assay

Activity 

  • [Ref.21029018]Herpes simplex virus type 1(HSV-1):inhibition of viral infection in human corneal epithelial (HCE) cells(EC50~30.0 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C56H104N30O17S

Absent amino acids  ADFHIKLMNPSTVWY

Common amino acids  R

Mass  1501.69

Pl  11.7

Basic residues  6

Acidic residues  2

Hydrophobic residues  0

Net charge  4

Boman Index  -10646

Hydrophobicity  -321.82

Aliphatic Index  0

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   A cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells.

Pubmed ID   21029018

Reference   J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7.

Author   Larsen IV, Brandt CR.

DOI   10.1089/jop.2010.0076