General Information

General Information

DRAVP ID DRAVPe01937

Peptide Name MDVgHH2L

Sequence NDSRGIDAEEELETKAELVITKLKTPLMRGKVVVGAAGA

Sequence Length 39

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism NDV,MDV

Assay Plaque formation assay

Activity

[Ref.24412629]Newcastle disease virus(NDV):inhibition of viral infection in chicken embryo fibroblasts(IC50=43.4 ± 2.0 μmol/L);
Marek's disease virus(MDV):inhibition of viral infection in chicken embryo fibroblasts(IC50=34.0 ± 2.00 μmol/L).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target membrane

Mechanism peptides from the hydrophobic fusogenic domains of gB and gH can block virus entry, disrupt cellular membranes by interacting with the cellular factors, or play a role in the glycoprotein conformational changes

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C177H306N50O59S

Absent amino acids CFHQWY

Common amino acids AE

Mass 4110.74

Pl 5.15

Basic residues 6

Acidic residues 7

Hydrophobic residues 15

Net charge -1

Boman Index -6044

Hydrophobicity -17.44

Aliphatic Index 102.56

Half Life

Mammalian:1.4 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 9

Literature Information

Literature 1

Title In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus.

Pubmed ID 24412629

Reference J Virol Methods. 2014 Apr;199:11-6.

Author Chi XJ, Wang XJ, Wang CY, Cui XJ, Wang XJ.

DOI 10.1016/j.jviromet.2013.12.022