DRAVP ID  DRAVPe01939

Peptide Name   NDVHR2

Sequence  LGNVNNSISNALDKLEESNSKLDKVNVKLTGTSAL

Sequence Length  35

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  NDV,MDV

Assay  Plaque formation assay

Activity 

• [Ref.24412629]Newcastle disease virus(NDV):inhibition of viral infection in chicken embryo fibroblasts(IC50=18.9 ± 2.8 μmol/L);
• Marek's disease virus(MDV):inhibition of viral infection in chicken embryo fibroblasts(IC50=65.3 ±0.9 μmol/L).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  peptides from the hydrophobic fusogenic domains of gB and gH can block virus entry, disrupt cellular membranes by interacting with the cellular factors, or play a role in the glycoprotein conformational changes

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus.

Pubmed ID   24412629

Reference   J Virol Methods. 2014 Apr;199:11-6.

Author   Chi XJ, Wang XJ, Wang CY, Cui XJ, Wang XJ.

DOI   10.1016/j.jviromet.2013.12.022