General Information

General Information

DRAVP ID DRAVPe01957

Peptide Name Dermaseptin S4 (1-16)[M4K]

Sequence ALWKTLLKKVLKAAAK

Sequence Length 16

UniProt ID P80280

Source Synthetic construct

Activity Information

Target Organism HIV

Assay Chemiluminescence Reporter Gene Assay

Activity

[Ref.15780876]human immunodeficiency virus type 1 (HIV-1):Inhibition of viral infection in Vero P4-CCR5 cells(IC50=28 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.15780876]P4-CCR5 cells:CC50>100 μM.

Binding Target viral membrane

Mechanism exerts a selective activity on viral particles and disturbs their organization by breaking the viral membrane, leading to the exposure of HIV-1 core and its dissociation.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C86H152N22O18

Absent amino acids CDEFGHIMNPQRSY

Common amino acids K

Mass 1782.29

Pl 10.6

Basic residues 5

Acidic residues 0

Hydrophobic residues 10

Net charge 5

Boman Index 297

Hydrophobicity 34.38

Aliphatic Index 140.63

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 366.67

Polar residues 1

Literature Information

Literature 1

Title The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro.

Pubmed ID 15780876

Reference Virology. 2005 Apr 10;334(2):264-75.

Author Lorin C, Saidi H, Belaid A, Zairi A, Baleux F, Hocini H, Bélec L, Hani K, Tangy F.

DOI 10.1016/j.virol.2005.02.002