General Information

General Information

DRAVP ID DRAVPe01959

Peptide Name Cicadin

Sequence NEYHGFVDKANNENKRKKQQGRDDFVVKPNNFANRRRKDDYNENYYDDVDAADVV

Sequence Length 55

UniProt ID P83282

Source Cicada flammata

Activity Information

Target Organism HIV

Assay ELISA

Activity

[Ref.11814612]HIV-1:inhibition the activity of reverse transcriptase(11.35±1.8% Inhibition at 0.1 µM, 85.8±2.3% Inhibition at 1 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C283H427N89O95

Absent amino acids CILMSTW

Common amino acids DN

Mass 6596.04

Pl 5.7

Basic residues 12

Acidic residues 12

Hydrophobic residues 13

Net charge 0

Boman Index -24057

Hydrophobicity -175.27

Aliphatic Index 38.91

Half Life

Mammalian:1.4 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 5960

Absorbance 280nm 110.37

Polar residues 15

Literature Information

Literature 1

Title Isolation of cicadin, a novel and potent antifungal peptide from dried juvenile cicadas.

Pubmed ID 11814612

Reference Peptides. 2002 Jan;23(1):7-11.

Author Wang H, Ng TB.

DOI 10.1016/s0196-9781(01)00573-3