DRAVP ID  DRAVPe01961

Peptide Name   Hepcidin TH2-3

Sequence  QSHLSLCRWCCNCCRSNKGC

Sequence Length  20

UniProt ID  I3KHK3 

Taxon ID  None

Source  Oreochromis mossambicus

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  FMDV

Assay  Plaque forming assay

Activity 

• [Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=25.1±1.5 µg/ml, IC90=78.5±7.6 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=120.2±2.5 µg/ml.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Cyclization(Cys7 and Cys20)

Other Modification  Disulfide bonds between Cys7 and Cys20, Cys10 and Cys13, Cys11 and Cys14.

Stereochemistry  L

Literature 1

Title   Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID   30012343

Reference   Peptides. 2018 Aug;106:91-95.

Author   Huang HN, Pan CY, Chen JY. 

DOI   10.1016/j.peptides.2018.07.003