DRAVP ID  DRAVPe01961

Peptide Name   Hepcidin TH2-3

Sequence  QSHLSLCRWCCNCCRSNKGC

Sequence Length  20

UniProt ID  I3KHK3 

Source  Oreochromis mossambicus

Target Organism  FMDV

Assay  Plaque forming assay

Activity 

• [Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=25.1±1.5 µg/ml, IC90=78.5±7.6 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=120.2±2.5 µg/ml.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Cyclization(Cys7 and Cys20)

Other Modification  Disulfide bonds between Cys7 and Cys20, Cys10 and Cys13, Cys11 and Cys14.

Stereochemistry  L

Literature 1

Title   Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID   30012343

Reference   Peptides. 2018 Aug;106:91-95.

Author   Huang HN, Pan CY, Chen JY. 

DOI   10.1016/j.peptides.2018.07.003