DRAVP ID  DRAVPe01964

Peptide Name   Epinecidin-1 (22-42)

Sequence  GFIFHIIKGLFHAGKMIHGLV

Sequence Length  21

UniProt ID  Q6JWQ9 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  FMDV

Assay  Plaque forming assay

Activity 

• [Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=0.6±0.1 µg/ml, IC90=12.5±1.1 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=19.5±3.1 µg/ml.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID   30012343

Reference   Peptides. 2018 Aug;106:91-95.

Author   Huang HN, Pan CY, Chen JY. 

DOI   10.1016/j.peptides.2018.07.003