General Information

General Information

DRAVP ID DRAVPe01964

Peptide Name Epinecidin-1 (22-42)

Sequence GFIFHIIKGLFHAGKMIHGLV

Sequence Length 21

UniProt ID Q6JWQ9

Source Synthetic construct

Activity Information

Target Organism FMDV

Assay Plaque forming assay

Activity

[Ref.30012343]Foot-and-Mouth Disease virus(FMDV):Inhibition of viral replication in BHK-21 cells(IC50=0.6±0.1 µg/ml, IC90=12.5±1.1 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30012343]Baby Hamster Kidney cells BHK-21:CC50=19.5±3.1 µg/ml.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C114H175N29O22S

Absent amino acids CDENPQRSTWY

Common amino acids GI

Mass 2335.88

Pl 10

Basic residues 5

Acidic residues 0

Hydrophobic residues 11

Net charge 5

Boman Index 2534

Hydrophobicity 109.05

Aliphatic Index 130

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro.

Pubmed ID 30012343

Reference Peptides. 2018 Aug;106:91-95.

Author Huang HN, Pan CY, Chen JY.

DOI 10.1016/j.peptides.2018.07.003