General Information

General Information

DRAVP ID DRAVPe01969

Peptide Name RJ8-R5W18

Sequence ARRARRRARRAARRARRWARR

Sequence Length 21

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HSV

Assay Not found

Activity

[Ref.16923027]Herpes simplex virus 1(HSV-1):inhibition of viral entry into Vero cells(IC50=9.2 µM); inhibition of viral infection in MRC-5 cells(IC50=2.8 µM);
Herpes simplex virus 2(HSV-2):inhibition of viral infection in MRC-5 cells(IC50=162 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C110H203N61O22

Absent amino acids CDEFGHIKLMNPQSTVY

Common amino acids R

Mass 2732.22

Pl 13.08

Basic residues 13

Acidic residues 0

Hydrophobic residues 8

Net charge 13

Boman Index -17896

Hydrophobicity -222.86

Aliphatic Index 33.33

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 275

Polar residues 0

Literature Information

Literature 1

Title Prediction of activity, synthesis and biological testing of anti-HSV active peptides.

Pubmed ID 16923027

Reference Chem Biol Drug Des. 2006 Jul;68(1):58-66.

Author Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.

DOI 10.1111/j.1747-0285.2006.00412.x