DRAVP ID  DRAVPe01969

Peptide Name   RJ8-R5W18

Sequence  ARRARRRARRAARRARRWARR

Sequence Length  21

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV

Assay  Not found

Activity 

• [Ref.16923027]Herpes simplex virus 1(HSV-1):inhibition of viral entry into Vero cells(IC50=9.2 µM); inhibition of viral infection in MRC-5 cells(IC50=2.8 µM);
• Herpes simplex virus 2(HSV-2):inhibition of viral infection in MRC-5 cells(IC50=162 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Prediction of activity, synthesis and biological testing of anti-HSV active peptides. 

Pubmed ID   16923027

Reference   Chem Biol Drug Des. 2006 Jul;68(1):58-66.

Author   Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.

DOI   10.1111/j.1747-0285.2006.00412.x