DRAVP ID  DRAVPe01970

Peptide Name   RJ2-W9,16

Sequence  KAAKKAAKWAKKAAKWAKKAA

Sequence Length  21

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  HSV

Assay  Not found

Activity 

• [Ref.16923027]Herpes simplex virus 1(HSV-1):inhibition of viral entry into Vero cells(IC50=111 µM); inhibition of viral infection in MRC-5 cells(IC50=32 µM);
• Herpes simplex virus 2(HSV-2):inhibition of viral infection in MRC-5 cells(IC50=48 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Prediction of activity, synthesis and biological testing of anti-HSV active peptides. 

Pubmed ID   16923027

Reference   Chem Biol Drug Des. 2006 Jul;68(1):58-66.

Author   Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.

DOI   10.1111/j.1747-0285.2006.00412.x