General Information


DRAVP ID  DRAVPe01971

Peptide Name   RJ2-Y2,9,16

Sequence  KYAKKAAKYAKKAAKYAKKAA

Sequence Length  21

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV

Assay  Not found

Activity 

  • [Ref.16923027]Herpes simplex virus 1(HSV-1):inhibition of viral entry into Vero cells(IC50=146 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C108H182N30O25

Absent amino acids  CDEFGHILMNPQRSTVW

Common amino acids  AK

Mass  2300.82

Pl  10.3

Basic residues  9

Acidic residues  0

Hydrophobic residues  9

Net charge  9

Boman Index  -3408

Hydrophobicity  -108.57

Aliphatic Index  42.86

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  4470

Absorbance 280nm  223.5

Polar residues  3



Literature Information


Literature 1

Title   Prediction of activity, synthesis and biological testing of anti-HSV active peptides. 

Pubmed ID   16923027

Reference   Chem Biol Drug Des. 2006 Jul;68(1):58-66.

Author   Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.

DOI   10.1111/j.1747-0285.2006.00412.x