General Information


DRAVP ID  DRAVPe01971

Peptide Name   RJ2-Y2,9,16

Sequence  KYAKKAAKYAKKAAKYAKKAA

Sequence Length  21

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV

Assay  Not found

Activity 

  • [Ref.16923027]Herpes simplex virus 1(HSV-1):inhibition of viral entry into Vero cells(IC50=146 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.16923027]No cytotoxicity against Human fibroblasts MRC-5 cells up to 448 µM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C108H182N30O25

Absent amino acids  CDEFGHILMNPQRSTVW

Common amino acids  AK

Mass  2300.82

Pl  10.3

Basic residues  9

Acidic residues  0

Hydrophobic residues  9

Net charge  9

Boman Index  -3408

Hydrophobicity  -108.57

Aliphatic Index  42.86

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  4470

Absorbance 280nm  223.5

Polar residues  3



Literature Information


Literature 1

Title   Prediction of activity, synthesis and biological testing of anti-HSV active peptides. 

Pubmed ID   16923027

Reference   Chem Biol Drug Des. 2006 Jul;68(1):58-66.

Author   Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T.

DOI   10.1111/j.1747-0285.2006.00412.x