General Information

General Information

DRAVP ID DRAVPe01976

Peptide Name CHR-5, Env GP (643-678)

Sequence HSLIEESQNQQEKNEQELLELDKWASLWNWFNITNW

Sequence Length 36

UniProt ID P04578

Source Synthetic construct

Activity Information

Target Organism HIV

Assay ELISA

Activity

[Ref.17276993]human immunodeficiency virus (HIV):inhibition of cell-cell fusion in MT-2 cells(IC50=2,185.00 ± 15.00 nM; IC90=2,858.00 ± 6.00 nM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism CHR-5 can bind to LUVs of POPC

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C203H295N53O64

Absent amino acids CGMPRVY

Common amino acids E

Mass 4501.89

Pl 4.3

Basic residues 3

Acidic residues 7

Hydrophobic residues 13

Net charge -4

Boman Index -8492

Hydrophobicity -114.17

Aliphatic Index 78.61

Half Life

Mammalian:3.5 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 22000

Absorbance 280nm 628.57

Polar residues 9

Literature Information

Literature 1

Title HIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides

Pubmed ID 17276993

Reference J Biol Chem. 2007 Mar 30;282(13):9612-9620.

Author Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S.

DOI 10.1074/jbc.M609148200