General Information

General Information

DRAVP ID DRAVPe01978

Peptide Name SARS-CoV S (192-203), SP-4

Sequence GFLYVYKGYQPI

Sequence Length 12

UniProt ID P59594

Source Synthetic construct

Activity Information

Target Organism SARS-CoV

Assay ELISA

Activity

[Ref.16337697]SARS-CoV:Inhibition of pseudovirus infection in Vero cells(IC50=4.30 ± 2.18 nM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target ACE2

Mechanism block the binding of S protein to ACE2.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C73H102N14O17

Absent amino acids ACDEHMNRSTW

Common amino acids Y

Mass 1447.7

Pl 8.43

Basic residues 1

Acidic residues 0

Hydrophobic residues 4

Net charge 1

Boman Index 723

Hydrophobicity 13.33

Aliphatic Index 89.17

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 4470

Absorbance 280nm 406.36

Polar residues 5

Literature Information

Literature 1

Title Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction.

Pubmed ID 16337697

Reference Antiviral Res. 2006 Feb;69(2):70-6.

Author Ho TY, Wu SL, Chen JC, Wei YC, Cheng SE, Chang YH, Liu HJ, Hsiang CY.

DOI 10.1016/j.antiviral.2005.10.005