To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01981
Peptide Name Peptide1(ACE2 (21-43)[N13Q,A16V,D18E,L19I,F20Y,Y21W])
Sequence IEEQAKTFLDKFQHEVEEIYWQS
Sequence Length 23
UniProt ID Q9BYF1
Source Synthetic construct
Activity Information
Target Organism SARS-CoV-2
Assay luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Spike protein
Mechanism antagonizes the SARS-CoV-2 S-RBD:ACE2 interaction and inhibits the virus entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C133H193N31O42
Absent amino acids CGMNPR
Common amino acids E
Mass 2898.18
Pl 4.41
Basic residues 3
Acidic residues 6
Hydrophobic residues 8
Net charge -3
Boman Index -5236
Hydrophobicity -94.78
Aliphatic Index 67.83
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 317.73
Polar residues 3
Literature Information
Literature 1
Title Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
Pubmed ID 34328726
Reference J Med Chem. 2022 Feb 24;65(4):2836-2847.
Author Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.