General Information

General Information

DRAVP ID DRAVPe01982

Peptide Name Peptide2

Sequence QDKHEEDYQMYNKGDKED

Sequence Length 18

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism SARS-CoV-2

Assay luciferase assay

Activity

[Ref.34328726]SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)(IC50=18 ± 2 nM, 95% inhibition at 0.39 µM, 100% inhibition at 25 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Spike protein

Mechanism antagonizes the SARS-CoV-2 S-RBD:ACE2 interaction and inhibits the virus entry.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C94H138N26O38S

Absent amino acids ACFILPRSTVW

Common amino acids D

Mass 2272.34

Pl 4.38

Basic residues 4

Acidic residues 7

Hydrophobic residues 0

Net charge -3

Boman Index -9133

Hydrophobicity -283.33

Aliphatic Index 0

Half Life

Mammalian:0.8 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 2980

Absorbance 280nm 175.29

Polar residues 4

Literature Information

Literature 1

Title Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein

Pubmed ID 34328726

Reference J Med Chem. 2022 Feb 24;65(4):2836-2847.

Author Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR.

DOI 10.1021/acs.jmedchem.1c00477