To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01986
Peptide Name Peptide6
Sequence SRDKHEEHEKENDRGQ
Sequence Length 16
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism SARS-CoV-2
Assay luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Spike protein
Mechanism antagonizes the SARS-CoV-2 S-RBD:ACE2 interaction and inhibits the virus entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C78H124N30O32
Absent amino acids ACFILMPTVWY
Common amino acids E
Mass 1994.02
Pl 5.43
Basic residues 6
Acidic residues 6
Hydrophobic residues 0
Net charge 0
Boman Index -10958
Hydrophobicity -327.5
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
Pubmed ID 34328726
Reference J Med Chem. 2022 Feb 24;65(4):2836-2847.
Author Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.