DRAVP ID  DRAVPe01990

Peptide Name   HBV S(56-80)

Sequence  PTSNHSPTSCPPTCPGYRWMCLRRF

Sequence Length  25

UniProt ID  O92921 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HBV

Assay  Scintillation count

Activity 

• [Ref.12469306]Hepatitis B virus(HBV): inhibition of the association of L-HBsAg with HBcAg(IC50=35±4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  core antigen (HBcAg)(Viral assembly)

Mechanism  During HBV morphogenesis, both the PreS and S domains of L-HBsAg form docking sites for the viral nucleocapsids. Thus, a compound that disrupts the interaction between the L-HBsAg and nucleocapsids could serve as a therapeutic agent against the virus based upon inhibition of morphogenesis. Peptide inhibits the association of L-HBsAg with core antigen (HBcAg).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of hepatitis B virus assembly with synthetic peptides derived from the viral surface and core antigens.

Pubmed ID   12469306

Reference   J Gen Appl Microbiol. 2002 Apr;48(2):103-7.

Author   Tan WS.

DOI   10.2323/jgam.48.103