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General Information
DRAVP ID DRAVPe01990
Peptide Name HBV S(56-80)
Sequence PTSNHSPTSCPPTCPGYRWMCLRRF
Sequence Length 25
UniProt ID O92921
Source Synthetic construct
Activity Information
Target Organism HBV
Assay Scintillation count
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target core antigen (HBcAg)(Viral assembly)
Mechanism During HBV morphogenesis, both the PreS and S domains of L-HBsAg form docking sites for the viral nucleocapsids. Thus, a compound that disrupts the interaction between the L-HBsAg and nucleocapsids could serve as a therapeutic agent against the virus based upon inhibition of morphogenesis. Peptide inhibits the association of L-HBsAg with core antigen (HBcAg).
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C125H188N38O34S4
Absent amino acids ADEIKQV
Common amino acids P
Mass 2895.34
Pl 9.27
Basic residues 4
Acidic residues 0
Hydrophobic residues 3
Net charge 4
Boman Index -5675
Hydrophobicity -77.2
Aliphatic Index 15.6
Half Life
Extinction Coefficient cystines 7115
Absorbance 280nm 296.46
Polar residues 12
Literature Information
Literature 1
Title Inhibition of hepatitis B virus assembly with synthetic peptides derived from the viral surface and core antigens.
Pubmed ID 12469306
Reference J Gen Appl Microbiol. 2002 Apr;48(2):103-7.
Author Tan WS.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.