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General Information
DRAVP ID DRAVPe01993
Peptide Name K6-10
Sequence GELGRPVYVLGDPGYYATHCIYATTNDALIFSV
Sequence Length 33
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HCV
Assay FRET assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target virus replication
Mechanism inhibitory peptides (IPs) capping the active site and binding via a novel "tyrosine" finger at an alternative NS3-6A site that is of particular interest。
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C164H243N39O49S
Absent amino acids KMQW
Common amino acids GY
Mass 3577.03
Pl 4.54
Basic residues 2
Acidic residues 3
Hydrophobic residues 12
Net charge -1
Boman Index -1197
Hydrophobicity 27.58
Aliphatic Index 94.55
Half Life
Extinction Coefficient cystines 5960
Absorbance 280nm 186.25
Polar residues 14
Literature Information
Literature 1
Title High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.
Pubmed ID 22965230
Reference J Biol Chem. 2012 Nov 9;287(46):39224-32.
Author Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.