To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02001
Peptide Name peptide 3
Sequence LKMDKLTLKGMSY
Sequence Length 13
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism DENV
Assay Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)
Activity [Ref.36739680]peptide 3 showed the most promising cell protection effects against DENV-1 (60.28%), DENV(36.23%), DENV-3 (73.85%), and DENV-4 (64.84%) at 200 μM. The IC50 of the cell protection effects of peptide 3 against DENV-3 was determined to be 182.27 μM; peptide 3 demonstrated the most promising antiviral activity during post-infection with good inhibitions of DENV-2 (69.05%) and DENV-3 (61.35%) whereas lower inhibitions were observed against DENV-1 (48.47%) and DENV-4 (34.72%) at 200 μM; Peptide 3 showed the highest inhibitions of plaque formations by DENV-2 (69.05%) and DENV-3 (61.35%); Peptide 3 reduced the RNA copy numbers of DENV-2 and DENV-3 by 43.83% and 50.72%, DENV-1 (31.85%); peptide 3 inhibited DENV-4 attachment to Vero cells by 39.58% but almost no inhibition was observed against DENV-1 (7.62%) and DENV-3 (2.56%).
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism It is possible that peptide 3 inhibited DENV-2 by inhibiting the virus particle itself and this was supported by the observation that peptide 3 showed good direct virus-inactivating effects against DENV-2.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C68H118N16O19S2
Absent amino acids ACEFHINPQRVW
Common amino acids KL
Mass 1527.9
Pl 9.529999999999999
Basic residues 3
Acidic residues 1
Hydrophobic residues 3
Net charge 2
Boman Index -1108
Hydrophobicity -24.62
Aliphatic Index 90
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 124.17
Polar residues 4
Literature Information
Literature 1
Title Development of novel antiviral peptides against dengue serotypes 1-4.
Pubmed ID 36739680
Reference Virology. 2023 Mar;580:10-27.
Author Lee MF, Anasir MI, Poh CL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.