To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02004
Peptide Name Peptide 6
Sequence IQTSGGTSI
Sequence Length 9
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism DENV
Assay Antiviral assays(Cell protection assay, Direct virus inhibition assay, Post-infection assay, Viral attachment assay, Viral entry assay)
Activity [Ref.36739680]Peptides 6 at 200 μM exhibited cell protection effects against DENV-1 (40.88%) and DENV-4 (51.27%), but lower inhibitory effects were observed against DENV-2 (10%) and DENV-3 (22.05%); Peptides 6 (200 μM) demonstrated inhibitions of all four DENV serotypes, but much lower inhibitions were observed against DENV-3 at 3.33%, respectively.
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C35H62N10O15
Absent amino acids ACDEFHKLMNPRVWY
Common amino acids GIST
Mass 862.94
Pl 5.52
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index -576
Hydrophobicity 18.89
Aliphatic Index 86.67
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Literature Information
Literature 1
Title Development of novel antiviral peptides against dengue serotypes 1-4.
Pubmed ID 36739680
Reference Virology. 2023 Mar;580:10-27.
Author Lee MF, Anasir MI, Poh CL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.